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Issue 45, 2013
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Total synthesis of (−)-kaitocephalin

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(−)-Kaitocephalin has been synthesized. With the C9 stereocenter from Garner's aldehyde, the C4 quaternary carbon was installed by the desymmetrization of the Cbz-protected serinol. The remaining stereogenic centers were generated through mercuriocyclization, epoxidation and regioselective epoxide opening, in which the quaternary carbon most likely played crucial roles in the stereoinduction.

Graphical abstract: Total synthesis of (−)-kaitocephalin

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The article was received on 01 Apr 2013, accepted on 17 Apr 2013 and first published on 30 Apr 2013

Article type: Communication
DOI: 10.1039/C3CC42365D
Citation: Chem. Commun., 2013,49, 5231-5233
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    Total synthesis of (−)-kaitocephalin

    W. Lee, J. Youn and S. H. Kang, Chem. Commun., 2013, 49, 5231
    DOI: 10.1039/C3CC42365D

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