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Issue 58, 2013
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Human lysozyme inhibits the in vitro aggregation of Aβ peptides, which in vivo are associated with Alzheimer's disease

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Abstract

Alzheimer's disease is a neurodegenerative disorder characterized by accumulation of Aβ peptide aggregates in the brain. Using ThT fluorescence assays, AFM imaging, NMR and CD spectroscopy, and MD modeling we show that lysozyme – a hydrolytic enzyme abundant in human secretions – completely inhibits the aggregation of Aβ peptides at equimolar lysozyme : Aβ peptide ratios.

Graphical abstract: Human lysozyme inhibits the in vitro aggregation of Aβ peptides, which in vivo are associated with Alzheimer's disease

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Publication details

The article was received on 30 Mar 2013, accepted on 29 May 2013 and first published on 29 May 2013


Article type: Communication
DOI: 10.1039/C3CC42325E
Citation: Chem. Commun., 2013,49, 6507-6509
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    Human lysozyme inhibits the in vitro aggregation of Aβ peptides, which in vivo are associated with Alzheimer's disease

    J. Luo, S. K. T. S. Wärmländer, A. Gräslund and J. P. Abrahams, Chem. Commun., 2013, 49, 6507
    DOI: 10.1039/C3CC42325E

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