Jump to main content
Jump to site search

Issue 41, 2013
Previous Article Next Article

Efficient synthesis of highly substituted pyrroles through a Pd(OCOCF3)2-catalyzed cascade reaction of 2-alkenal-1,3-dicarbonyl compounds with primary amines

Author affiliations

Abstract

We describe an unprecedented Pd(OCOCF3)2-catalyzed cascade process for the synthesis of highly functionalized 1,2,3,5-tetrasubstituted pyrroles with high efficiency. Unlike documented methods relying on preformed enamines and active halogenated terminal alkenes, the process employs simple 2-alkenal-dicarbonyls and primary amines in ‘one-pot’.

Graphical abstract: Efficient synthesis of highly substituted pyrroles through a Pd(OCOCF3)2-catalyzed cascade reaction of 2-alkenal-1,3-dicarbonyl compounds with primary amines

Back to tab navigation

Supplementary files

Publication details

The article was received on 26 Mar 2013, accepted on 02 Apr 2013 and first published on 03 Apr 2013


Article type: Communication
DOI: 10.1039/C3CC42216J
Citation: Chem. Commun., 2013,49, 4667-4669
  •   Request permissions

    Efficient synthesis of highly substituted pyrroles through a Pd(OCOCF3)2-catalyzed cascade reaction of 2-alkenal-1,3-dicarbonyl compounds with primary amines

    W. Yang, L. Huang, H. Liu, W. Wang and H. Li, Chem. Commun., 2013, 49, 4667
    DOI: 10.1039/C3CC42216J

Search articles by author

Spotlight

Advertisements