Jump to main content
Jump to site search

Issue 51, 2013
Previous Article Next Article

Thioflavin-T excimer formation upon interaction with amyloid fibers

Author affiliations

Abstract

The molecular mechanism of the Thioflavin-T (Th-T) binding to amyloids remains unknown. By combining experimental analysis of Th-T excitation and emission spectra with theoretical calculations we suggest that Th-T fluorescence changes upon interaction with amyloids may arise from the formation of an excimer with an oblique angle of ∼120 degrees.

Graphical abstract: Thioflavin-T excimer formation upon interaction with amyloid fibers

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 20 Mar 2013, accepted on 30 Apr 2013 and first published on 30 Apr 2013


Article type: Communication
DOI: 10.1039/C3CC42040J
Citation: Chem. Commun., 2013,49, 5745-5747
  •   Request permissions

    Thioflavin-T excimer formation upon interaction with amyloid fibers

    R. Sabate, L. Rodriguez-Santiago, M. Sodupe, S. J. Saupe and S. Ventura, Chem. Commun., 2013, 49, 5745
    DOI: 10.1039/C3CC42040J

Search articles by author