Thioflavin-T excimer formation upon interaction with amyloid fibers

Raimon Sabate; Luis Rodriguez-Santiago; Mariona Sodupe; Sven J. Saupe; Salvador Ventura

doi:10.1039/C3CC42040J

skip Feedback

Home > Journals > Chemical Communications > Thioflavin-T excimer fo...

For Authors & Referees | For Librarians | For Members

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Chemical Communications

Issue 51, 2013

Urgent high quality communications from across the chemical sciences.

Impact Factor 6.378 100 Issues per Year Indexed in MEDLINE

Journal Home

Previous Article | Next Article

Communication

Thioflavin-T excimer formation upon interaction with amyloid fibers

Raimon Sabate,*^a Luis Rodriguez-Santiago,^b Mariona Sodupe,^b Sven J. Saupe^c and Salvador Ventura^d

Show Affiliations

Hide Affiliations

Corresponding authors

Institut de Nanociència i nanotecnologia, Departament Fisicoquímica, Universitat de Barcelona, Joan XXIII s/n, E-08028-Barcelona, Spain
E-mail: rsabate@ub.edu;
Fax: +34 934035987 ;
Tel: +34 934035986

Departament de Química, Universitat Autònoma de Barcelona, 08193-Bellaterra, Spain

Institut de Biochimie et de Génétique Cellulaire, UMR 5095, CNRS – Université de Bordeaux 2, 33077 Bordeaux cedex, France

Institut de Biotecnologia i Biomedicina, Departament Bioquímica, Universitat Autònoma de Barcelona, 08193-Bellaterra, Spain

Chem. Commun., 2013,49, 5745-5747

DOI: 10.1039/C3CC42040J
Received 20 Mar 2013, Accepted 30 Apr 2013
First published online 30 Apr 2013

Please wait while Download options loads

Download Citation

Request Permissions

Abstract
Cited by
Related Content

The molecular mechanism of the Thioflavin-T (Th-T) binding to amyloids remains unknown. By combining experimental analysis of Th-T excitation and emission spectra with theoretical calculations we suggest that Th-T fluorescence changes upon interaction with amyloids may arise from the formation of an excimer with an oblique angle of [similar] 120 degrees.