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Issue 61, 2013
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Selective cleavage of 3,5-bis-(trifluoromethyl)benzylcarbamate by SmI2–Et3N–H2O

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Abstract

A novel electron poor protection group for amines has been developed. It undergoes rapid cleavage by SmI2–Et3N–H2O and its orthogonality towards the regular benzyl carbamate group (CBz) under reductive or transfer hydrogenolytic conditions is reported.

Graphical abstract: Selective cleavage of 3,5-bis-(trifluoromethyl)benzylcarbamate by SmI2–Et3N–H2O

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Publication details

The article was received on 04 Mar 2013, accepted on 05 Jun 2013 and first published on 06 Jun 2013


Article type: Communication
DOI: 10.1039/C3CC41642A
Citation: Chem. Commun., 2013,49, 6867-6869
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    Selective cleavage of 3,5-bis-(trifluoromethyl)benzylcarbamate by SmI2–Et3N–H2O

    T. Ankner, A. Said Stålsmeden and G. Hilmersson, Chem. Commun., 2013, 49, 6867
    DOI: 10.1039/C3CC41642A

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