Jump to main content
Jump to site search

Issue 40, 2013
Previous Article Next Article

Stereoselective titanium-mediated aldol reactions of a chiral isopropyl ketone

Author affiliations

Abstract

A novel substrate-controlled aldol reaction of a chiral isopropyl ketone is reported. The outstanding regioselective enolization by TiCl4–i-Pr2NEt provides a chelated enolate that can participate in highly diastereoselective additions to a wide array of aldehydes favouring the corresponding 2,5-syn adducts.

Graphical abstract: Stereoselective titanium-mediated aldol reactions of a chiral isopropyl ketone

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 04 Mar 2013, accepted on 28 Mar 2013 and first published on 28 Mar 2013


Article type: Communication
DOI: 10.1039/C3CC41640B
Citation: Chem. Commun., 2013,49, 4507-4509
  •   Request permissions

    Stereoselective titanium-mediated aldol reactions of a chiral isopropyl ketone

    J. Zambrana, P. Romea and F. Urpí, Chem. Commun., 2013, 49, 4507
    DOI: 10.1039/C3CC41640B

Search articles by author