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Issue 57, 2013
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A novel array format for monitoring cellular uptake using a photo-cleavable linker for peptide release

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Abstract

We developed a novel peptide array format incorporating a photo-cleavable linker for monitoring cellular uptake. Model peptides were successfully immobilised via the photo-cleavable linker onto conventional plates and could be released spatiotemporally using UV irradiation. Incorporation of confocal microscopy allowed for detailed real-time monitoring of cellular internalisation of peptides.

Graphical abstract: A novel array format for monitoring cellular uptake using a photo-cleavable linker for peptide release

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Publication details

The article was received on 04 Mar 2013, accepted on 22 May 2013 and first published on 10 Jun 2013


Article type: Communication
DOI: 10.1039/C3CC41632A
Citation: Chem. Commun., 2013,49, 6394-6396
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    A novel array format for monitoring cellular uptake using a photo-cleavable linker for peptide release

    K. Usui, T. Kikuchi, K. Tomizaki, T. Kakiyama and H. Mihara, Chem. Commun., 2013, 49, 6394
    DOI: 10.1039/C3CC41632A

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