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Issue 41, 2013
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Pd-catalyzed diastereoselective allylation of aldehydes with 3-bromomethyl-5H-furan-2-one: stereoselective synthesis of β-(hydroxymethylaryl/alkyl)-α-methylene-γ-butyrolactones with a syn configuration

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Abstract

An efficient and diastereoselective Pd-catalyzed method of allylation of aldehydes with 3-bromomethyl-5H-furan-2-one is described. The proposed method allows the synthesis of β-(hydroxymethylaryl/alkyl)-α-methylene-γ-butyrolactones with a syn relative configuration for the first time.

Graphical abstract: Pd-catalyzed diastereoselective allylation of aldehydes with 3-bromomethyl-5H-furan-2-one: stereoselective synthesis of β-(hydroxymethylaryl/alkyl)-α-methylene-γ-butyrolactones with a syn configuration

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Publication details

The article was received on 28 Feb 2013, accepted on 03 Apr 2013 and first published on 05 Apr 2013


Article type: Communication
DOI: 10.1039/C3CC41501E
Citation: Chem. Commun., 2013,49, 4697-4699
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    Pd-catalyzed diastereoselective allylation of aldehydes with 3-bromomethyl-5H-furan-2-one: stereoselective synthesis of β-(hydroxymethylaryl/alkyl)-α-methylene-γ-butyrolactones with a syn configuration

    F. Zhang, Y. Yang, L. Xie and X. Xu, Chem. Commun., 2013, 49, 4697
    DOI: 10.1039/C3CC41501E

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