Vinylic amino group activation: a new and general strategy leading to functionalized fused heteroaromatics

Rajnikanth Sunke; Raju Adepu; Ravikumar Kapavarapu; Swetha Chintala; Chandana Lakshmi Teja Meda; Kishore V. L. Parsa; Manojit Pal

doi:10.1039/C3CC41337C

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Chemical Communications

Issue 34, 2013

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Vinylic amino group activation: a new and general strategy leading to functionalized fused heteroaromatics

Rajnikanth Sunke,^a Raju Adepu,^a Ravikumar Kapavarapu,^b Swetha Chintala,^a Chandana Lakshmi Teja Meda,^a Kishore V. L. Parsa^a and Manojit Pal*^a

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Dr Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, India
E-mail: manojitpal@rediffmail.com ;
Tel: +91 40 6657 1500

Doctoral Programme in Experimental Biology and Biomedicine, Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal

Chem. Commun., 2013,49, 3570-3572

DOI: 10.1039/C3CC41337C
Received 22 Feb 2013, Accepted 11 Mar 2013
First published online 13 Mar 2013

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A conceptually new and general strategy has been developed for the construction of a benzimidazole or a benzoxazole ring fused with isoquinolinone affording a diverse and unique class of small molecules as potential and novel inhibitors of PDE4.