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Issue 34, 2013
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Vinylic amino group activation: a new and general strategy leading to functionalized fused heteroaromatics

Rajnikanth Sunke,a  Raju Adepu,a  Ravikumar Kapavarapu,b  Swetha Chintala,a  Chandana Lakshmi Teja Meda,a  Kishore V. L. Parsaa  and  Manojit Pal*a 
Author affiliations

* Corresponding authors

a Dr Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, India
E-mail: manojitpal@rediffmail.com
Tel: +91 40 6657 1500

b Doctoral Programme in Experimental Biology and Biomedicine, Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal

Abstract

A conceptually new and general strategy has been developed for the construction of a benzimidazole or a benzoxazole ring fused with isoquinolinone affording a diverse and unique class of small molecules as potential and novel inhibitors of PDE4.

Graphical abstract: Vinylic amino group activation: a new and general strategy leading to functionalized fused heteroaromatics

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Publication details

The article was received on 22 Feb 2013, accepted on 11 Mar 2013 and first published on 13 Mar 2013


Article type: Communication
DOI: 10.1039/C3CC41337C
Citation: Chem. Commun., 2013,49, 3570-3572
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    Vinylic amino group activation: a new and general strategy leading to functionalized fused heteroaromatics

    R. Sunke, R. Adepu, R. Kapavarapu, S. Chintala, C. L. T. Meda, K. V. L. Parsa and M. Pal, Chem. Commun., 2013, 49, 3570
    DOI: 10.1039/C3CC41337C

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