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Issue 35, 2013
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A regioselective synthesis of 1-haloisoquinolines via ruthenium-catalyzed cyclization of O-methylbenzohydroximoyl halides with alkynes

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Abstract

A ruthenium-catalyzed highly regioselective cyclization of substituted N-methoxy benzimidoyl halides with alkynes in the presence of CsOAc (25 mol%) to give substituted 1-halo and 1-alkoxy substituted isoquinolines in good to excellent yields is described.

Graphical abstract: A regioselective synthesis of 1-haloisoquinolines via ruthenium-catalyzed cyclization of O-methylbenzohydroximoyl halides with alkynes

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Publication details

The article was received on 18 Feb 2013, accepted on 13 Mar 2013 and first published on 14 Mar 2013


Article type: Communication
DOI: 10.1039/C3CC41269E
Citation: Chem. Commun., 2013,49, 3703-3705
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    A regioselective synthesis of 1-haloisoquinolines via ruthenium-catalyzed cyclization of O-methylbenzohydroximoyl halides with alkynes

    R. K. Chinnagolla, S. Pimparkar and M. Jeganmohan, Chem. Commun., 2013, 49, 3703
    DOI: 10.1039/C3CC41269E

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