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Issue 45, 2013
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Exploration of the medical periodic table: towards new targets

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Abstract

Metallodrugs offer potential for unique mechanisms of drug action based on the choice of the metal, its oxidation state, the types and number of coordinated ligands and the coordination geometry. We discuss recent progress in identifying new target sites and elucidating the mechanisms of action of anti-cancer, anti-bacterial, anti-viral, anti-parasitic, anti-inflammatory, and anti-neurodegenerative agents, as well as in the design of metal-based diagnostic agents. Progress in identifying and defining target sites has been accelerated recently by advances in proteomics, genomics and metal speciation analysis. Examples of metal compounds and chelating agents (enzyme inhibitors) currently in clinical use, clinical trials or preclinical development are highlighted.

Graphical abstract: Exploration of the medical periodic table: towards new targets

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Publication details

The article was received on 11 Feb 2013, accepted on 03 Apr 2013 and first published on 01 May 2013


Article type: Feature Article
DOI: 10.1039/C3CC41143E
Citation: Chem. Commun., 2013,49, 5106-5131
  • Open access: Creative Commons BY license
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    Exploration of the medical periodic table: towards new targets

    N. P. E. Barry and P. J. Sadler, Chem. Commun., 2013, 49, 5106
    DOI: 10.1039/C3CC41143E

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