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Issue 36, 2013
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Development of a 11C-labeled tetrazine for rapid tetrazinetrans-cyclooctene ligation

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Abstract

Tetrazinetrans-cyclooctene ligations are remarkably fast and selective reactions even at low micro-molar concentrations. In bioorthogonal radiochemistry, tools that enable conjugation of radioactive probes to pre-targeted vectors are of great interest. Herein, we describe the successful development of the first 11C-labelled tetrazine and its reaction with trans-cyclooctenol.

Graphical abstract: Development of a 11C-labeled tetrazine for rapid tetrazine–trans-cyclooctene ligation

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Publication details

The article was received on 06 Feb 2013, accepted on 18 Mar 2013 and first published on 18 Mar 2013


Article type: Communication
DOI: 10.1039/C3CC41027G
Citation: Chem. Commun., 2013,49, 3805-3807
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    Development of a 11C-labeled tetrazine for rapid tetrazinetrans-cyclooctene ligation

    M. M. Herth, V. L. Andersen, S. Lehel, J. Madsen, G. M. Knudsen and J. L. Kristensen, Chem. Commun., 2013, 49, 3805
    DOI: 10.1039/C3CC41027G

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