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Issue 47, 2013
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Luminescent organoplatinum(II) complexes containing bis(N-heterocyclic carbene) ligands selectively target the endoplasmic reticulum and induce potent photo-toxicity

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Abstract

A panel of luminescent platinum(II) complexes containing bidentate N-heterocyclic carbene ligands selectively localize to the endoplasmic reticulum (ER) domain, induce ER stress and cell apoptosis. Some of them show potent photo-toxicity to cancer cells.

Graphical abstract: Luminescent organoplatinum(ii) complexes containing bis(N-heterocyclic carbene) ligands selectively target the endoplasmic reticulum and induce potent photo-toxicity

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Publication details

The article was received on 04 Feb 2013, accepted on 11 Mar 2013 and first published on 21 Mar 2013


Article type: Communication
DOI: 10.1039/C3CC40953H
Citation: Chem. Commun., 2013,49, 5423-5425
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    Luminescent organoplatinum(II) complexes containing bis(N-heterocyclic carbene) ligands selectively target the endoplasmic reticulum and induce potent photo-toxicity

    T. Zou, C. Lok, Y. M. E. Fung and C. Che, Chem. Commun., 2013, 49, 5423
    DOI: 10.1039/C3CC40953H

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