A Pt(II)–Dip complex stabilizes parallel c-myc G-quadruplex

Jintao Wang; Kaihui Lu; Shuguang Xuan; Zaozhen Toh; Dawei Zhang; Fangwei Shao

doi:10.1039/C3CC40868J

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Chemical Communications

Issue 42, 2013

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A Pt(II)–Dip complex stabilizes parallel c-myc G-quadruplex

Jintao Wang,^a Kaihui Lu,^a Shuguang Xuan,^a Zaozhen Toh,^a Dawei Zhang*^a and Fangwei Shao*^a

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Division of Chemistry and Biological Chemistry, Nanyang Technological University, 21 Nanyang Link, Singapore
E-mail: fwshao@ntu.edu.sg, zhangdw@ntu.edu.sg;
Fax: +65 6791-1961 ;
Tel: +65 6592-2511

Chem. Commun., 2013,49, 4758-4760

DOI: 10.1039/C3CC40868J
Received 01 Feb 2013, Accepted 02 Apr 2013
First published online 03 Apr 2013

This article is part of themed collection: Medicinal Inorganic Chemistry

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Abstract
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A new G-quadruplex (GQ) stabilizer, [Pt(Dip)₂](PF₆)₂ (Dip: 4,7-diphenyl-1,10-phenanthroline), is prepared by the microwave irradiation method. The complex can highly stabilize G-quadruplex, but has negligible interactions with duplex DNA. Aromatic anchors on the polypyridyl ligands bestow the stabilizer with a high binding preference towards parallel GQ.