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Issue 42, 2013
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A Pt(II)–Dip complex stabilizes parallel c-myc G-quadruplex

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Abstract

A new G-quadruplex (GQ) stabilizer, [Pt(Dip)2](PF6)2 (Dip: 4,7-diphenyl-1,10-phenanthroline), is prepared by the microwave irradiation method. The complex can highly stabilize G-quadruplex, but has negligible interactions with duplex DNA. Aromatic anchors on the polypyridyl ligands bestow the stabilizer with a high binding preference towards parallel GQ.

Graphical abstract: A Pt(ii)–Dip complex stabilizes parallel c-myc G-quadruplex

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Publication details

The article was received on 01 Feb 2013, accepted on 02 Apr 2013 and first published on 03 Apr 2013


Article type: Communication
DOI: 10.1039/C3CC40868J
Citation: Chem. Commun., 2013,49, 4758-4760
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    A Pt(II)–Dip complex stabilizes parallel c-myc G-quadruplex

    J. Wang, K. Lu, S. Xuan, Z. Toh, D. Zhang and F. Shao, Chem. Commun., 2013, 49, 4758
    DOI: 10.1039/C3CC40868J

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