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Issue 38, 2013
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Thienopyrrole-expanded BODIPY as a potential NIR photosensitizer for photodynamic therapy

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Abstract

The synthesis and characterization of a highly photostable bromo-substituted BODIPY dye (I) fused-ring-expanded with thienopyrrole moieties is reported. The results of MTT assays and flow cytometric analyses in living HeLa cells demonstrate that I has a high singlet oxygen quantum yield (ΦΔ = 0.63) and exhibits photocytotoxicity upon irradiation in the NIR region making it potentially suitable for use in PDT.

Graphical abstract: Thienopyrrole-expanded BODIPY as a potential NIR photosensitizer for photodynamic therapy

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Publication details

The article was received on 29 Jan 2013, accepted on 06 Mar 2013 and first published on 13 Mar 2013


Article type: Communication
DOI: 10.1039/C3CC40746B
Citation: Chem. Commun., 2013,49, 3940-3942
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    Thienopyrrole-expanded BODIPY as a potential NIR photosensitizer for photodynamic therapy

    Y. Yang, Q. Guo, H. Chen, Z. Zhou, Z. Guo and Z. Shen, Chem. Commun., 2013, 49, 3940
    DOI: 10.1039/C3CC40746B

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