Translating the concept of peptide labeling with 5-deoxy-5-[18F]fluororibose into preclinical practice: 18F-labeling of Siglec-9 peptide for PET imaging of inflammation

Xiang-Guo Li; Anu Autio; Helena Ahtinen; Kerttuli Helariutta; Heidi Liljenbäck; Sirpa Jalkanen; Anne Roivainen; Anu J. Airaksinen

doi:10.1039/C3CC40738A

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Chemical Communications

Issue 35, 2013

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Impact Factor 6.169 100 Issues per Year Indexed in MEDLINE

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Translating the concept of peptide labeling with 5-deoxy-5-[¹⁸F]fluororibose into preclinical practice: ¹⁸F-labeling of Siglec-9 peptide for PET imaging of inflammation

Xiang-Guo Li,*^a^b Anu Autio,^b Helena Ahtinen,^b Kerttuli Helariutta,^c Heidi Liljenbäck,^b^d Sirpa Jalkanen,^e Anne Roivainen*^b^d and Anu J. Airaksinen*^c

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Department of Pharmacology, Drug Development and Therapeutics, University of Turku, FI-20014 Turku, Finland
E-mail: xiali@utu.fi

Turku PET Centre, University of Turku and Turku University Hospital, FI-20521 Turku, Finland
E-mail: anne.roivainen@utu.fi

Laboratory of Radiochemistry, Department of Chemistry, University of Helsinki, FI-00014 Helsinki, Finland
E-mail: anu.airaksinen@helsinki.fi

Turku Center for Disease Modeling, University of Turku, FI-20014 Turku, Finland

MediCity Research Laboratory and Department of Medical Microbiology and Immunology, University of Turku, FI-20014 Turku, Finland

Chem. Commun., 2013,49, 3682-3684

DOI: 10.1039/C3CC40738A
Received 29 Jan 2013, Accepted 15 Mar 2013
First published online 15 Mar 2013

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Peptide glycosylation with 5-deoxy-5-[¹⁸F]fluororibose was translated into preclinical settings. The novel ¹⁸F-labeled Siglec-9 peptide was produced using an automated synthesis procedure. The ¹⁸F-labeled Siglec-9 peptide showed favorable binding in the animal model of inflammation in vivo.

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Xiang-Guo Li
Anu Autio
Helena Ahtinen
Kerttuli Helariutta
Heidi Liljenbäck
Sirpa Jalkanen
Anne Roivainen
Anu J. Airaksinen

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Chemical Communications

Translating the concept of peptide labeling with 5-deoxy-5-[¹⁸F]fluororibose into preclinical practice: ¹⁸F-labeling of Siglec-9 peptide for PET imaging of inflammation

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Chemical Communications

Translating the concept of peptide labeling with 5-deoxy-5-[18F]fluororibose into preclinical practice: 18F-labeling of Siglec-9 peptide for PET imaging of inflammation

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Translating the concept of peptide labeling with 5-deoxy-5-[¹⁸F]fluororibose into preclinical practice: ¹⁸F-labeling of Siglec-9 peptide for PET imaging of inflammation