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Issue 53, 2013
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A click-activated fluorescent probe for selective detection of hydrazoic acid and its application in biological imaging

Yi Zhou,a  Yue-Wei Yao,ab  Qi Qi,b  Yuan Fang,a  Jing-Yun Lic  and  Cheng Yao*a 
Author affiliations

* Corresponding authors

a State Key Laboratory of Materials-Oriented Chemical Engineering and College of Science, Nanjing University of Technology, Nanjing 210009, P. R. China
E-mail: yaochengnjut@126.com
Fax: +86-25-8358-7433

b College of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, P. R. China

c Model Animal Research Center, Nanjing University, Nanjing 210061, P. R. China

Abstract

Here we present a new approach to aqueous hydrazoic acid detection through the synthesis and evaluation of an alkyne-based fluorescent probe, which could be applied in the monitoring of hydrazoic acid in both living Hela cells and larval zebrafish. This probe can also serve as an early warning automaton which would alert when both azide and protons exist over the threshold value.

Graphical abstract: A click-activated fluorescent probe for selective detection of hydrazoic acid and its application in biological imaging

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Publication details

The article was received on 27 Jan 2013, accepted on 09 Mar 2013 and first published on 13 Mar 2013


Article type: Communication
DOI: 10.1039/C3CC40698A
Citation: Chem. Commun., 2013,49, 5924-5926
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    A click-activated fluorescent probe for selective detection of hydrazoic acid and its application in biological imaging

    Y. Zhou, Y. Yao, Q. Qi, Y. Fang, J. Li and C. Yao, Chem. Commun., 2013, 49, 5924
    DOI: 10.1039/C3CC40698A

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