Issue 51, 2013

Concise solid-phase synthesis of inverse poly(amidoamine) dendrons using AB2 building blocks

Abstract

A concise solid-phase synthesis of inverse poly(amidoamine) dendrons was developed. Upon introduction of AB2-type monomers, each dendron generation was constructed via one reaction. G2 to G5 dendrons were constructed in a peptide synthesizer in 93%, 89%, 82%, and 78% yields, respectively, within 5 days.

Graphical abstract: Concise solid-phase synthesis of inverse poly(amidoamine) dendrons using AB2 building blocks

Supplementary files

Article information

Article type
Communication
Submitted
25 Jan 2013
Accepted
03 Apr 2013
First published
04 Apr 2013

Chem. Commun., 2013,49, 5784-5786

Concise solid-phase synthesis of inverse poly(amidoamine) dendrons using AB2 building blocks

A. Y. Huang, C. Tsai, H. Chen, H. Chen, C. Lu, Y. Lin and C. Kao, Chem. Commun., 2013, 49, 5784 DOI: 10.1039/C3CC40661J

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