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Issue 32, 2013
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A cascade approach to fused indolizinones through Lewis acid–copper(I) relay catalysis

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Abstract

A relay catalytic cascade process involving Lewis acid triggered ring-opening of cyclopropyl ketones with nitriles, the copper(I)-catalyzed Ritter process, and acid-promoted N-acyliminium ion cyclization is described, which efficiently provides thieno-, furano-, and benzo-indolizinones in moderate to good yields.

Graphical abstract: A cascade approach to fused indolizinones through Lewis acid–copper(i) relay catalysis

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Publication details

The article was received on 25 Jan 2013, accepted on 05 Mar 2013 and first published on 06 Mar 2013


Article type: Communication
DOI: 10.1039/C3CC40643A
Citation: Chem. Commun., 2013,49, 3351-3353
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    A cascade approach to fused indolizinones through Lewis acid–copper(I) relay catalysis

    H. Huang, X. Ji, W. Wu and H. Jiang, Chem. Commun., 2013, 49, 3351
    DOI: 10.1039/C3CC40643A

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