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Issue 40, 2013
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Synthesis of 1,5-triazole bridged vancomycin CDE-ring bicyclic mimics using RuAAC macrocyclization

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Abstract

Herein we report the Ru(II)-catalyzed double-macrocyclization of a hexapeptide to obtain a mimic of the bicyclic CDE-ring of vancomycin, followed by measurement of its binding affinity for small peptide ligands using ITC.

Graphical abstract: Synthesis of 1,5-triazole bridged vancomycin CDE-ring bicyclic mimics using RuAAC macrocyclization

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Supplementary files

Publication details

The article was received on 24 Jan 2013, accepted on 27 Mar 2013 and first published on 28 Mar 2013


Article type: Communication
DOI: 10.1039/C3CC40628H
Citation: Chem. Commun., 2013,49, 4498-4500
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    Synthesis of 1,5-triazole bridged vancomycin CDE-ring bicyclic mimics using RuAAC macrocyclization

    J. Zhang, J. Kemmink, D. T. S. Rijkers and R. M. J. Liskamp, Chem. Commun., 2013, 49, 4498
    DOI: 10.1039/C3CC40628H

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