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Issue 28, 2013
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Exploiting furan's versatile reactivity in reversible and irreversible orthogonal peptide labeling

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Abstract

A general method for the facile and versatile decoration of peptides is proposed exploiting furan based cycloaddition and electrophilic aromatic substitution reactions. Given the commercial availability of furylalanine derivatives for peptide synthesis, the current work significantly enlarges the toolbox of available methodologies for site specific labeling and conjugation of peptide probes.

Graphical abstract: Exploiting furan's versatile reactivity in reversible and irreversible orthogonal peptide labeling

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Publication details

The article was received on 23 Jan 2013, accepted on 21 Feb 2013 and first published on 22 Feb 2013


Article type: Communication
DOI: 10.1039/C3CC40588E
Citation: Chem. Commun., 2013,49, 2927-2929
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    Exploiting furan's versatile reactivity in reversible and irreversible orthogonal peptide labeling

    K. Hoogewijs, D. Buyst, J. M. Winne, J. C. Martins and A. Madder, Chem. Commun., 2013, 49, 2927
    DOI: 10.1039/C3CC40588E

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