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Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Australia
; Fax: +61-7-3346-2090
; Tel: +61-7-3346-2985
Chem. Commun., 2013,49, 2356-2358
22 Jan 2013,
06 Feb 2013
First published online
08 Feb 2013
We report the total chemical synthesis of human C3a by one-pot native chemical ligation of three unprotected peptide segments, followed by efficient in vitro folding that yielded the anaphylatoxin C3a in high yield and excellent purity. Synthetic C3a was fully active and its crystal structure at 2.1 Å resolution showed 3 helices and a C-terminal turn motif.
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