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Issue 23, 2013
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Efficient chemical synthesis of human complement protein C3a

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Abstract

We report the total chemical synthesis of human C3a by one-pot native chemical ligation of three unprotected peptide segments, followed by efficient in vitro folding that yielded the anaphylatoxin C3a in high yield and excellent purity. Synthetic C3a was fully active and its crystal structure at 2.1 Å resolution showed 3 helices and a C-terminal turn motif.

Graphical abstract: Efficient chemical synthesis of human complement protein C3a

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Publication details

The article was received on 22 Jan 2013, accepted on 06 Feb 2013 and first published on 08 Feb 2013


Article type: Communication
DOI: 10.1039/C3CC40537K
Citation: Chem. Commun., 2013,49, 2356-2358
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    Efficient chemical synthesis of human complement protein C3a

    A. Ghassemian, C. A. Wang, M. Yau, R. C. Reid, R. J. Lewis, D. P. Fairlie, P. F. Alewood and T. Durek, Chem. Commun., 2013, 49, 2356
    DOI: 10.1039/C3CC40537K

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