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Issue 22, 2013
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Orthanilic acid-promoted reverse turn formation in peptides

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Orthanilic acid (2-aminobenzenesulfonic acid, SAnt), an aromatic β-amino acid, has been shown to be highly useful in inducing a folded conformation in peptides. When incorporated into peptide sequences (Xaa-SAnt-Yaa), this rigid aromatic β-amino acid strongly imparts a reverse-turn conformation to the peptide backbone, featuring robust 11-membered-ring hydrogen-bonding.

Graphical abstract: Orthanilic acid-promoted reverse turn formation in peptides

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Publication details

The article was received on 19 Nov 2012, accepted on 30 Jan 2013 and first published on 30 Jan 2013

Article type: Communication
DOI: 10.1039/C3CC40522B
Citation: Chem. Commun., 2013,49, 2222-2224
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    Orthanilic acid-promoted reverse turn formation in peptides

    S. S. Kale, G. Priya, A. S. Kotmale, R. L. Gawade, V. G. Puranik, P. R. Rajamohanan and G. J. Sanjayan, Chem. Commun., 2013, 49, 2222
    DOI: 10.1039/C3CC40522B

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