The first total synthesis of Rolloamide B, a cyclic proline-enriched heptapeptide, is reported. This work features solution phase benzotriazole-mediated peptide synthesis ligating native amino acids.
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Total synthesis of cyclic heptapeptide Rolloamide B
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a
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, USA
E-mail: katritzky@chem.ufl.edu
E-mail: katritzky@chem.ufl.edu
b
Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig-44519, Egypt
c
Department of Organic Chemistry, College of Pharmacy, Misr University for Science and Technology, Al-Motamayez District, 6th of October, P.O. Box: 77, Egypt
d
Department of Chemistry, King Abdulaziz University, Jeddah, Saudi Arabia
Chem. Commun., 2013,49, 2631-2633
DOI: 10.1039/C3CC39291K
Received 30 Dec 2012, Accepted 23 Jan 2013
First published online 24 Jan 2013
Chemical Communications
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