Benzo-fused cyclobutanols were developed as novel DNA cleaving molecules. The molecules nick a strand of supercoiled DNA under acidic conditions. By contrast, almost no activity was observed under neutral or basic conditions.
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pH-sensitive DNA cleaving agents: in situ activation by ring contraction of benzo-fused cyclobutanols
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Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 505-8501, Japan
E-mail: kay-t@pharm.kyoto-u.ac.jp ;
Fax: +81-75-753-4604 ;
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E-mail: kay-t@pharm.kyoto-u.ac.jp ;
Fax: +81-75-753-4604 ;
Tel: +81-75-753-4553
Chem. Commun., 2013,49, 2622-2624
DOI: 10.1039/C3CC39246E
Received 28 Dec 2012, Accepted 13 Feb 2013
First published online 14 Feb 2013
Chemical Communications
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