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Issue 41, 2013
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P450 BM3 crystal structures reveal the role of the charged surface residue Lys/Arg184 in inversion of enantioselective styrene epoxidation

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Abstract

Solved crystal structures of P450 BM3 variants in complex with styrene provide on the molecular level a first explanation of how a positively charged surface residue inverts the enantiopreference of styrene epoxidation. The obtained insights into productive and non-productive styrene binding modes deepened our understanding of enantioselective epoxidation with P450 BM3.

Graphical abstract: P450 BM3 crystal structures reveal the role of the charged surface residue Lys/Arg184 in inversion of enantioselective styrene epoxidation

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Publication details

The article was received on 19 Dec 2012, accepted on 04 Apr 2013 and first published on 05 Apr 2013


Article type: Communication
DOI: 10.1039/C3CC39076D
Citation: Chem. Commun., 2013,49, 4694-4696
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    P450 BM3 crystal structures reveal the role of the charged surface residue Lys/Arg184 in inversion of enantioselective styrene epoxidation

    A. Shehzad, S. Panneerselvam, M. Linow, M. Bocola, D. Roccatano, J. Mueller-Dieckmann, M. Wilmanns and U. Schwaneberg, Chem. Commun., 2013, 49, 4694
    DOI: 10.1039/C3CC39076D

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