A dinucleating ligand which promotes DNA cleavage with one and without a transition metal ion

Javier Hernández-Gil; Sacramento Ferrer; Elena Salvador; Javier Calvo; Enrique Garcia-España; Juan C. Mareque-Rivas

doi:10.1039/C3CC39067E

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Chemical Communications

Issue 35, 2013

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A dinucleating ligand which promotes DNA cleavage with one and without a transition metal ion

Javier Hernández-Gil,^a Sacramento Ferrer,*^a Elena Salvador,^b Javier Calvo,^c Enrique Garcia-España^b and Juan C. Mareque-Rivas*^c^d

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Departament de Química Inorgànica, Facultat de Farmàcia, Universitat de València, 46100-Burjassot, Valencia, Spain
E-mail: sacramento.ferrer@uv.es ;
Fax: +34-96-354-4960 ;
Tel: +34-96-354-4521

Departamento de Química, Inorgànica, Universidad de Valencia, Instituto de Ciencia Molecular, Edificio de Institutos de Paterna Apdo 22085, Valencia, Spain

Cooperative Centre for Research in Biomaterials (CiC biomaGUNE), 20009 San Sebastián, Spain
E-mail: jmareque@cicbiomagune.es ;
Fax: +34 943 005301 ;
Tel: +34 943 005313

Ikerbasque, Basque Foundation for Science, 48011 Bilbao, Spain

Chem. Commun., 2013,49, 3655-3657

DOI: 10.1039/C3CC39067E
Received 19 Dec 2012, Accepted 13 Mar 2013
First published online 14 Mar 2013

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The dinucleating ligand L (1,3-bis[bis(pyridin-2-ylmethyl)amino]propan-2-ol) combined with metal ions efficiently cleaves DNA when M:L is 1:1 (M = Co(II) or Fe(III)) at pH 5.5–7.0, with free L being more active at acidic pH than when bound to Zn(II), Cu(II) or Ni(II) at neutral pH.