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Issue 35, 2013
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A dinucleating ligand which promotes DNA cleavage with one and without a transition metal ion

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Abstract

The dinucleating ligand L (1,3-bis[bis(pyridin-2-ylmethyl)amino]propan-2-ol) combined with metal ions efficiently cleaves DNA when M : L is 1 : 1 (M = Co(II) or Fe(III)) at pH 5.5–7.0, with free L being more active at acidic pH than when bound to Zn(II), Cu(II) or Ni(II) at neutral pH.

Graphical abstract: A dinucleating ligand which promotes DNA cleavage with one and without a transition metal ion

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Publication details

The article was received on 19 Dec 2012, accepted on 13 Mar 2013 and first published on 14 Mar 2013


Article type: Communication
DOI: 10.1039/C3CC39067E
Citation: Chem. Commun., 2013,49, 3655-3657
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    A dinucleating ligand which promotes DNA cleavage with one and without a transition metal ion

    J. Hernández-Gil, S. Ferrer, E. Salvador, J. Calvo, E. Garcia-España and J. C. Mareque-Rivas, Chem. Commun., 2013, 49, 3655
    DOI: 10.1039/C3CC39067E

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