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Issue 26, 2013
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A novel label-free cascade amplification strategy based on dumbbell probe-mediated rolling circle amplification-responsive G-quadruplex formation for highly sensitive and selective detection of NAD+ or ATP

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Abstract

A novel label-free fluorescent sensing scheme for sensitive and selective detection of NAD+ and ATP has been developed based on dumbbell probe-mediated rolling circle amplification (D-RCA)-responsive G-quadruplex formation. This approach can detect 0.5 pM for ATP and 100 fM for NAD+, much lower than those of previously reported biosensors, and exhibits high discrimination ability.

Graphical abstract: A novel label-free cascade amplification strategy based on dumbbell probe-mediated rolling circle amplification-responsive G-quadruplex formation for highly sensitive and selective detection of NAD+ or ATP

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Publication details

The article was received on 19 Dec 2012, accepted on 06 Feb 2013 and first published on 07 Feb 2013


Article type: Communication
DOI: 10.1039/C3CC39064K
Citation: Chem. Commun., 2013,49, 2640-2642
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    A novel label-free cascade amplification strategy based on dumbbell probe-mediated rolling circle amplification-responsive G-quadruplex formation for highly sensitive and selective detection of NAD+ or ATP

    Q. Xue, L. Wang and W. Jiang, Chem. Commun., 2013, 49, 2640
    DOI: 10.1039/C3CC39064K

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