The first synthesis of kottamide E, a marine natural product containing a 5,6-dibromoindole linked via a (Z)-enamide to an unusual 1,2-dithiolane-containing amino acid, is reported.
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Total synthesis of kottamide E
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School of Chemistry, University of Birmingham, Edgbaston, Birmingham, UK
E-mail: r.s.grainger@bham.ac.uk ;
Fax: +44 (0)121 4144403 ;
Tel: +44 (0)121 4144465
E-mail: r.s.grainger@bham.ac.uk ;
Fax: +44 (0)121 4144403 ;
Tel: +44 (0)121 4144465
Chem. Commun., 2013,49, 2296-2298
DOI: 10.1039/C3CC39062D
Received 19 Dec 2012, Accepted 01 Feb 2013
First published online 01 Feb 2013
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