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Issue 16, 2013
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Asymmetric direct α-alkylation of 2-oxindoles with Michler's hydrol catalyzed by bis-cinchona alkaloid–Brønsted acid via an SN1-type pathway

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Abstract

An enantioselective direct α-alkylation of 2-oxindoles with Michler's hydrol via an SN1-type pathway in the non-covalent activation mode using the bis-cinchona alkaloid and Brønsted acid as a co-catalyst was developed and good to high yields and enantioselectivities were obtained.

Graphical abstract: Asymmetric direct α-alkylation of 2-oxindoles with Michler's hydrol catalyzed by bis-cinchona alkaloid–Brønsted acid via an SN1-type pathway

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Publication details

The article was received on 19 Oct 2012, accepted on 08 Jan 2013 and first published on 09 Jan 2013


Article type: Communication
DOI: 10.1039/C3CC39012H
Citation: Chem. Commun., 2013,49, 1636-1638
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    Asymmetric direct α-alkylation of 2-oxindoles with Michler's hydrol catalyzed by bis-cinchona alkaloid–Brønsted acid via an SN1-type pathway

    T. Zhang, Z. Qiao, Y. Wang, N. Zhong, L. Liu, D. Wang and Y. Chen, Chem. Commun., 2013, 49, 1636
    DOI: 10.1039/C3CC39012H

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