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Asymmetric direct α-alkylation of 2-oxindoles with Michler's hydrol catalyzed by bis-cinchona alkaloid–Brønsted acid via an SN1-type pathway

Tao Zhang,ab   Zhen Qiao,ab   Yan Wang,ab   Nengjun Zhong,ab   Li Liu,*a   Dong Wanga and   Yong-Jun Chena  
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a
Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
E-mail: lliu@iccas.ac.cn;
Fax: +86 10 6255 4449 ;
Tel: +86 10 6255 4614
b
Graduate School of Chinese Academy of Sciences, Beijing 100049, China
Chem. Commun., 2013,49, 1636-1638

DOI: 10.1039/C3CC39012H
Received 19 Oct 2012, Accepted 08 Jan 2013
First published online 09 Jan 2013
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