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Issue 26, 2013
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Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization

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Abstract

hIAPP fibrillization implicated in Type 2 diabetes pathology involves formation of oligomers toxic to insulin producing pancreatic β-cells. We report design, synthesis, 3D structure and functional characterization of dehydrophenylalanine (ΔF) containing peptides which inhibit hIAPP fibrillization. The inhibitor protects β-cells from hIAPP induced toxicity.

Graphical abstract: Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization

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Publication details

The article was received on 16 Dec 2012, accepted on 11 Feb 2013, published on 13 Feb 2013 and first published online on 13 Feb 2013


Article type: Communication
DOI: 10.1039/C3CC38982K
Citation: Chem. Commun., 2013,49, 2688-2690
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    Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization

    A. Mishra, A. Misra, T. Sri Vaishnavi, C. Thota, M. Gupta, S. Ramakumar and V. S. Chauhan, Chem. Commun., 2013, 49, 2688
    DOI: 10.1039/C3CC38982K

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