Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization

Aseem Mishra; Anurag Misra; T. Sri Vaishnavi; Chaitanya Thota; Madhvi Gupta; Suryanarayanarao Ramakumar; Virander Singh Chauhan

doi:10.1039/C3CC38982K

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Chemical Communications

Issue 26, 2013

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Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization

Aseem Mishra,^a Anurag Misra,^b T. Sri Vaishnavi,^a Chaitanya Thota,^a Madhvi Gupta,^a Suryanarayanarao Ramakumar*^b and Virander Singh Chauhan*^a

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International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110067, India
E-mail: virander@icgeb.res.in ;
Fax: +91-11-26742316 ;
Tel: +91-11-26741358

Department of Physics, Indian Institute of Science, Bangalore 560012, India
E-mail: ramak@physics.iisc.ernet.in ;
Tel: +91-80-22932312

Chem. Commun., 2013,49, 2688-2690

DOI: 10.1039/C3CC38982K
Received 16 Dec 2012, Accepted 11 Feb 2013
First published online 13 Feb 2013

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Abstract
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hIAPP fibrillization implicated in Type 2 diabetes pathology involves formation of oligomers toxic to insulin producing pancreatic β-cells. We report design, synthesis, 3D structure and functional characterization of dehydrophenylalanine (ΔF) containing peptides which inhibit hIAPP fibrillization. The inhibitor protects β-cells from hIAPP induced toxicity.

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Aseem Mishra
Anurag Misra
T. Sri Vaishnavi
Chaitanya Thota
Madhvi Gupta
Suryanarayanarao Ramakumar
Virander Singh Chauhan

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Chemical Communications

Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization

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