A novel method of electrochemical methylation-specific ligation detection reaction is first presented for simultaneous evaluation of multiple gene-methylation loci in a single-tube experiment without PCR amplification or restriction enzyme reaction.
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Simultaneous profiling of multiple gene-methylation loci by electrochemical methylation-specific ligase detection reaction
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School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, P. R. China
E-mail: daizong@mail.sysu.edu.cn ;
Fax: +86 20 84112245 ;
Tel: +86 20 84114919
E-mail: daizong@mail.sysu.edu.cn ;
Fax: +86 20 84112245 ;
Tel: +86 20 84114919
Chem. Commun., 2013,49, 1939-1941
DOI: 10.1039/C3CC38942A
Received 14 Dec 2012, Accepted 18 Jan 2013
First published online 21 Jan 2013
Chemical Communications
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