Issue 17, 2013
From the journal:

Chemical Communications

Single-molecule DNA detection using a novel SP1 protein nanopore†

Hai-Yan Wang,a   Yang Li,a   Li-Xia Qin,a   Arnon Heyman,b   Oded Shoseyov,b   Itamar Willner,*c   Yi-Tao Long*a  and  He Tian*a  

* Corresponding authors

a Key Laboratory for Advanced Materials and Institute of Fine Chemicals & Department of Chemistry, East China University of Science and Technology Shanghai, P. R. China
E-mail: yitaolong@ecust.edu.cn, tianhe@ecust.edu.cn
Fax: +86 021 64252339

b The Robert H. Smith Institute of Plant Sciences and Genetics in Agriculture, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Israel

c Institute of Chemistry, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem, Israel
E-mail: willnea@vms.huji.ac.il
Fax: +972-2-6527715

Abstract

SP1 protein as a new type of biological nanopore is described and is utilized to distinguish single-stranded DNA at the single-molecule level. Using the SP1 nanopore to investigate single molecule detection broadens the existing research areas of pore-forming biomaterials from unsymmetrical biological nanopores to symmetrical biological nanopores. This novel nanopore could provide a good candidate for single-molecule detection and characterization of biomaterial applications.

Graphical abstract: Single-molecule DNA detection using a novel SP1 protein nanopore

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Article information

DOI
https://doi.org/10.1039/C3CC38939A
Article type
Communication
Submitted
14 Dec 2012
Accepted
10 Jan 2013
First published
11 Jan 2013

Chem. Commun., 2013,49, 1741-1743

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Single-molecule DNA detection using a novel SP1 protein nanopore

H. Wang, Y. Li, L. Qin, A. Heyman, O. Shoseyov, I. Willner, Y. Long and H. Tian, Chem. Commun., 2013, 49, 1741 DOI: 10.1039/C3CC38939A

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