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Issue 35, 2013
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Controlling the rate of coiled coil driven membrane fusion

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Abstract

Sets of complementary lipidated coiled-coil forming peptides that fuse membrane fusion have been designed. The influence of the coiled-coil motif on the rate of liposome fusion was studied, by varying the number of heptad repeats. We found that an increased coiled-coil stability of complementary peptides translates into increased rates of membrane fusion of liposomes.

Graphical abstract: Controlling the rate of coiled coil driven membrane fusion

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Publication details

The article was received on 13 Dec 2012, accepted on 08 Mar 2013 and first published on 13 Mar 2013


Article type: Communication
DOI: 10.1039/C3CC38926J
Citation: Chem. Commun., 2013,49, 3649-3651
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    Controlling the rate of coiled coil driven membrane fusion

    T. Zheng, J. Voskuhl, F. Versluis, H. R. Zope, I. Tomatsu, H. R. Marsden and A. Kros, Chem. Commun., 2013, 49, 3649
    DOI: 10.1039/C3CC38926J

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