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Issue 25, 2013
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Highly diastereoselective synthesis of 3-indolylglycines via an asymmetric oxidative heterocoupling reaction of a chiral nickel(II) complex and indoles

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Abstract

The asymmetric synthesis of 3-indolylglycine derivatives was achieved by an oxidative heterocoupling reaction. This method for the selective C-3 functionalization of unprotected indoles with the chiral equivalent of a nucleophilic glycine nickel(II) complex afforded adducts with high diastereoselectivities. The decomposition of adducts readily afforded 3-indolylglycine derivatives in high yields.

Graphical abstract: Highly diastereoselective synthesis of 3-indolylglycines via an asymmetric oxidative heterocoupling reaction of a chiral nickel(ii) complex and indoles

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Publication details

The article was received on 13 Dec 2012, accepted on 05 Feb 2013, published on 06 Feb 2013 and first published online on 06 Feb 2013


Article type: Communication
DOI: 10.1039/C3CC38908A
Citation: Chem. Commun., 2013,49, 2575-2577
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    Highly diastereoselective synthesis of 3-indolylglycines via an asymmetric oxidative heterocoupling reaction of a chiral nickel(II) complex and indoles

    D. Lin, J. Wang, X. Zhang, S. Zhou, J. Lian, H. Jiang and H. Liu, Chem. Commun., 2013, 49, 2575
    DOI: 10.1039/C3CC38908A

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