TokyoGreen derivatives as specific and practical fluorescent probes for UDP-glucuronosyltransferase (UGT) 1A1

Takuya Terai; Rie Tomiyasu; Tomoe Ota; Tasuku Ueno; Toru Komatsu; Kenjiro Hanaoka; Yasuteru Urano; Tetsuo Nagano

doi:10.1039/C3CC38810G

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Chemical Communications

Issue 30, 2013

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TokyoGreen derivatives as specific and practical fluorescent probes for UDP-glucuronosyltransferase (UGT) 1A1

Takuya Terai,^a Rie Tomiyasu,^a Tomoe Ota,^a Tasuku Ueno,^a Toru Komatsu,^a Kenjiro Hanaoka,^a Yasuteru Urano*^b and Tetsuo Nagano*^a

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Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan
E-mail: tlong@mol.f.u-tokyo.ac.jp ;
Fax: +81-3-5841-4855 ;
Tel: +81-3-5841-4850

Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan
E-mail: uranokun@m.u-tokyo.ac.jp ;
Tel: +81-3-5841-3601

Chem. Commun., 2013,49, 3101-3103

DOI: 10.1039/C3CC38810G
Received 08 Dec 2012, Accepted 07 Jan 2013
First published online 21 Jan 2013

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Abstract
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TokyoGreen (TG) derivatives were found to be efficient and specific substrates of an important drug-metabolizing enzyme, UDP-glucuronosyltransferase (UGT) 1A1. A rapid, specific, and sensitive assay of the enzyme was achieved simply by monitoring the change in fluorescence intensity. We also designed and developed the first “turn-on” fluorescent probes for UGTs.

Abstract from Analytical Abstracts 2013

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Takuya Terai
Rie Tomiyasu
Tomoe Ota
Tasuku Ueno
Toru Komatsu
Kenjiro Hanaoka
Yasuteru Urano
Tetsuo Nagano

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Chemical Communications

TokyoGreen derivatives as specific and practical fluorescent probes for UDP-glucuronosyltransferase (UGT) 1A1

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Chemical Communications

TokyoGreen derivatives as specific and practical fluorescent probes for UDP-glucuronosyltransferase (UGT) 1A1

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