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Issue 37, 2013
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Directed evolution of a synthetic RNA–protein module to create a new translational switch

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Abstract

A synthetic RNP-binding module was developed to produce an alternative translational switch: an in vitro selection experiment targeting a derivative of L7Ae protein (L7KK) identified a new H23 RNA aptamer that binds tightly to both L7KK and L7Ae. The switch serves as a translational OFF switch for constructing a NOR gate.

Graphical abstract: Directed evolution of a synthetic RNA–protein module to create a new translational switch

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Publication details

The article was received on 04 Dec 2012, accepted on 17 Jan 2013 and first published on 21 Jan 2013


Article type: Communication
DOI: 10.1039/C3CC38688K
Citation: Chem. Commun., 2013,49, 3833-3835
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    Directed evolution of a synthetic RNA–protein module to create a new translational switch

    T. Hara, H. Saito and T. Inoue, Chem. Commun., 2013, 49, 3833
    DOI: 10.1039/C3CC38688K

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