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Issue 19, 2013
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Site-selective three-component reaction for dual-functionalization of peptides

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Abstract

A site-selective dual-functionalization of peptides is presented, involving readily available maleimides as well as N-hydroxylamines. The modification proceeds through a three component 1,3-dipolar cycloaddition, forming a stable product. This was exemplified by the one-pot attachment of two molecular imaging moieties to a tumor binding cyclic peptide, and was extended to the conjugation of a DOTA chelator to a 12 kDa protein.

Graphical abstract: Site-selective three-component reaction for dual-functionalization of peptides

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Publication details

The article was received on 03 Dec 2012, accepted on 21 Jan 2013 and first published on 22 Jan 2013


Article type: Communication
DOI: 10.1039/C3CC38673B
Citation: Chem. Commun., 2013,49, 1936-1938
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    Site-selective three-component reaction for dual-functionalization of peptides

    H. K. Munch, J. E. Rasmussen, G. Popa, J. B. Christensen and K. J. Jensen, Chem. Commun., 2013, 49, 1936
    DOI: 10.1039/C3CC38673B

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