A universal and multiplex kinase assay using γ-[18O4]-ATP

Chuan Fu; Xueyun Zheng; Yao Jiang; Yan Liu; Pengxiang Xu; Zhiping Zeng; Rihe Liu; Yufen Zhao

doi:10.1039/C3CC38467E

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Chemical Communications

Issue 27, 2013

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A universal and multiplex kinase assay using γ-[¹⁸O₄]-ATP

Chuan Fu,^a Xueyun Zheng,^a Yao Jiang,^a Yan Liu,^a Pengxiang Xu,^a Zhiping Zeng,^a Rihe Liu^b and Yufen Zhao*^a

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Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, P.R.China
E-mail: yfzhao@xmu.edu.cn

Eshelman School of Pharmacy and Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, USA

Chem. Commun., 2013,49, 2795-2797

DOI: 10.1039/C3CC38467E
Received 25 Nov 2012, Accepted 16 Jan 2013
First published online 18 Jan 2013

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We have synthesized γ-[¹⁸O₄]-ATP and used it to develop a non-radioactive and multiplex method. Significantly, this novel approach can be applied to any kinases without using a purified enzyme or a fluorescent substrate. Using this approach, the effectiveness and specificity of inhibitors on several kinases could be readily determined.

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Chuan Fu
Xueyun Zheng
Yao Jiang
Yan Liu
Pengxiang Xu
Zhiping Zeng
Rihe Liu
Yufen Zhao

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