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Issue 17, 2013
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Auto-tandem catalysis: synthesis of 4H-pyrido[1,2-a]pyrimidin-4-ones via copper-catalyzed aza-Michael addition–aerobic dehydrogenation–intramolecular amidation

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Abstract

A copper-catalyzed domino synthesis of 4H-pyrido[1,2-a]pyrimidin-4-ones has been developed from 1,4-enediones and 2-aminoheterocycles with air as the oxidant.

Graphical abstract: Auto-tandem catalysis: synthesis of 4H-pyrido[1,2-a]pyrimidin-4-ones via copper-catalyzed aza-Michael addition–aerobic dehydrogenation–intramolecular amidation

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Publication details

The article was received on 10 Nov 2012, accepted on 11 Jan 2013 and first published on 11 Jan 2013


Article type: Communication
DOI: 10.1039/C3CC38131E
Citation: Chem. Commun., 2013,49, 1729-1731
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    Auto-tandem catalysis: synthesis of 4H-pyrido[1,2-a]pyrimidin-4-ones via copper-catalyzed aza-Michael addition–aerobic dehydrogenation–intramolecular amidation

    Y. Yang, W. Shu, S. Yu, F. Ni, M. Gao and A. Wu, Chem. Commun., 2013, 49, 1729
    DOI: 10.1039/C3CC38131E

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