A copper-catalyzed domino synthesis of 4H-pyrido[1,2-a]pyrimidin-4-ones has been developed from 1,4-enediones and 2-aminoheterocycles with air as the oxidant.
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Auto-tandem catalysis: synthesis of 4H-pyrido[1,2-a]pyrimidin-4-ones via copper-catalyzed aza-Michael addition–aerobic dehydrogenation–intramolecular amidation
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Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China
E-mail: chwuax@mail.ccnu.edu.cn
E-mail: chwuax@mail.ccnu.edu.cn
Chem. Commun., 2013,49, 1729-1731
DOI: 10.1039/C3CC38131E
Received 10 Nov 2012, Accepted 11 Jan 2013
First published online 11 Jan 2013
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