Issue 17, 2013
From the journal:

Chemical Communications

Auto-tandem catalysis: synthesis of 4H-pyrido[1,2-a]pyrimidin-4-ones via copper-catalyzed aza-Michael addition–aerobic dehydrogenation–intramolecular amidation†

Yan Yang,a   Wen-Ming Shu,a   Shang-Bo Yu,a   Fan Ni,a   Meng Gaoa  and  An-Xin Wu*a  

* Corresponding authors

a Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, Hubei, P. R. China
E-mail: chwuax@mail.ccnu.edu.cn

Abstract

A copper-catalyzed domino synthesis of 4H-pyrido[1,2-a]pyrimidin-4-ones has been developed from 1,4-enediones and 2-aminoheterocycles with air as the oxidant.

Graphical abstract: Auto-tandem catalysis: synthesis of 4H-pyrido[1,2-a]pyrimidin-4-ones via copper-catalyzed aza-Michael addition–aerobic dehydrogenation–intramolecular amidation

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Article information

DOI
https://doi.org/10.1039/C3CC38131E
Article type
Communication
Submitted
10 Nov 2012
Accepted
11 Jan 2013
First published
11 Jan 2013

Chem. Commun., 2013,49, 1729-1731

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Auto-tandem catalysis: synthesis of 4H-pyrido[1,2-a]pyrimidin-4-ones via copper-catalyzed aza-Michael addition–aerobic dehydrogenation–intramolecular amidation

Y. Yang, W. Shu, S. Yu, F. Ni, M. Gao and A. Wu, Chem. Commun., 2013, 49, 1729 DOI: 10.1039/C3CC38131E

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