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Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room B3 C346A, 10 Center Drive, Bethesda, USA
; Fax: +1 301 480 5112
; Tel: +1 301 594 5986
Chem. Commun., 2013,49, 2151-2153
26 Oct 2012,
29 Jan 2013
First published online
30 Jan 2013
No-carrier-added [18F]fluoroarenes were synthesized through the radiofluorination of diaryl sulfoxides with [18F]fluoride ion. Diaryl sulfoxides bearing a para electron-withdrawing substituent readily gave the corresponding 4-[18F]fluoroarenes in high RCYs. This process broadens the scope for preparing novel 18F-labeling synthons and PET radiotracers.
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