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Issue 37, 2013
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Asymmetric organocatalysis mediated by α,α-L-diaryl prolinols: recent advances

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Abstract

This feature article illustrates progress in asymmetric organocatalysis achieved by using readily available α,α-L-diaryl prolinols from 2009 up to middle 2012. This class of bifunctional organocatalysts has shown the ability to catalyze a variety of reactions such as epoxidation, cyclopropanation, α-sulfenylation of active methines, cross conjugate addition, direct aldol, cycloaddition and desymmetrization reactions. The most striking feature of these promoters is to enable either non-covalent or covalent activation of the reagents, thus distinguishing themselves as a rare example of organic promoters capable of encompassing alternative mechanistic pathways, namely enamine/iminium catalysis and Brønsted acid/base catalysis.

Graphical abstract: Asymmetric organocatalysis mediated by α,α-l-diaryl prolinols: recent advances

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Publication details

The article was received on 24 Sep 2012, accepted on 13 Mar 2013 and first published on 14 Mar 2013


Article type: Feature Article
DOI: 10.1039/C3CC36928E
Citation: Chem. Commun., 2013,49, 3821-3832
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    Asymmetric organocatalysis mediated by α,α-L-diaryl prolinols: recent advances

    S. Meninno and A. Lattanzi, Chem. Commun., 2013, 49, 3821
    DOI: 10.1039/C3CC36928E

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