Branched peptide boronic acids (BPBAs): a novel mode of binding towards RNA

Wenyu Zhang; David I. Bryson; Jason B. Crumpton; Jessica Wynn; Webster L. Santos

doi:10.1039/C3CC00243H

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Chemical Communications

Issue 24, 2013

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Branched peptide boronic acids (BPBAs): a novel mode of binding towards RNA

Wenyu Zhang,^a David I. Bryson,^a Jason B. Crumpton,^a Jessica Wynn^a and Webster L. Santos*^a

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Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, Virginia 24061, USA
E-mail: santosw@vt.edu ;
Fax: +1 540 231 3255 ;
Tel: +1 540 231 5041

Chem. Commun., 2013,49, 2436-2438

DOI: 10.1039/C3CC00243H
Received 10 Jan 2013, Accepted 07 Feb 2013
First published online 07 Feb 2013

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Abstract
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We report branched peptide boronic acids (BPBAs) that bind to RRE IIB from an on-bead high-throughput screening of a 3.3.4-library (46656 compounds). We demonstrate that boronic acids are tunable moieties that afford a novel binding mode towards RNA.