Switchable delivery of small interfering RNA using a negatively charged pH-responsive polyethylenimine-based polyelectrolyte complex

S.-Ja. Tseng; Yi-Fang Zeng; Yu-Fan Deng; Pan-Chyr Yang; Je-Ruei Liu; Ivan M. Kempson

doi:10.1039/C3CC00134B

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Chemical Communications

Issue 26, 2013

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Switchable delivery of small interfering RNA using a negatively charged pH-responsive polyethylenimine-based polyelectrolyte complex

S.-Ja. Tseng,^a Yi-Fang Zeng,^b Yu-Fan Deng,^c Pan-Chyr Yang,^d Je-Ruei Liu*^b^e^f and Ivan M. Kempson*^a^g

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Institute of Physics, Academia Sinica, Taipei 115, Taiwan

Institute of Biotechnology, National Taiwan University, Taipei 106, Taiwan
E-mail: jrliu@ntu.edu.tw

Department of Industrial Engineering and Enterprise Information, Tunghai University, Taichung 407, Taiwan

Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100, Taiwan

Department of Animal Science and Technology, National Taiwan University, Taipei 106, Taiwan

Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan

Ian Wark Research Institute, University of South Australia, Mawson Lakes, Australia
E-mail: Ivan.Kempson@unisa.edu.au ;
Fax: +61 8 8302 3683 ;
Tel: +61 8 8302 3694

Chem. Commun., 2013,49, 2670-2672

DOI: 10.1039/C3CC00134B
Received 07 Jan 2013, Accepted 12 Feb 2013
First published online 13 Feb 2013

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A small interfering RNA (siRNA)-loaded polyelectrolyte constructed with branched polyethylenimine (bPEI) and copolymers, consisting of polyethylene glycol (PEG), histidine (His), and glutamic acid (Glu), was developed in order to provide a tumor acidosis-triggered delivery system with low cytotoxicity.

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Yi-Fang Zeng
Yu-Fan Deng
Pan-Chyr Yang
Je-Ruei Liu
Ivan M. Kempson

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