Issue 21, 2013
From the journal:

Chemical Communications

Aminocatalyzed asymmetric Diels–Alder reaction of 2,4-dienals and rhodanine/hydantoin derivatives†

Kailong Zhu,a   Huicai Huang,a   Wenbin Wu,a   Yuan Weia  and  Jinxing Ye*a  

* Corresponding authors

a Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China
E-mail: yejx@ecust.edu.cn

Abstract

Aminocatalyzed asymmetric Diels–Alder reaction between 2,4-dienals and rhodanine/hydantoin derivatives via trienamine mechanism has been developed to synthesize various spirocyclic compounds with good yields (up to 98%) and excellent stereoselectivities (up to 99% ee and >19 : 1 dr).

Graphical abstract: Aminocatalyzed asymmetric Diels–Alder reaction of 2,4-dienals and rhodanine/hydantoin derivatives

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Article information

DOI
https://doi.org/10.1039/C3CC00023K
Article type
Communication
Submitted
02 Jan 2013
Accepted
23 Jan 2013
First published
07 Feb 2013

Chem. Commun., 2013,49, 2157-2159

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Aminocatalyzed asymmetric Diels–Alder reaction of 2,4-dienals and rhodanine/hydantoin derivatives

K. Zhu, H. Huang, W. Wu, Y. Wei and J. Ye, Chem. Commun., 2013, 49, 2157 DOI: 10.1039/C3CC00023K

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