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Issue 16, 2013
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Stereoselective access to heteroarylmethylene-substituted pyrrolidines: fully organocatalytic Mannich–hydroamination reactions

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Abstract

A one-pot sequence of organocatalytic transformations delivers heteroarylmethylene-substituted pyrrolidines with high stereo- and enantioselectivity. A Mannich coupling of N-heteroarylalkyne aldehydes with aldimine and an original metal-free hydroamination of the resulting adducts are the key transformations of the process delivering highly functionalized molecules with high potential for synthetic applications.

Graphical abstract: Stereoselective access to heteroarylmethylene-substituted pyrrolidines: fully organocatalytic Mannich–hydroamination reactions

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Publication details

The article was received on 14 Dec 2012, accepted on 01 Jan 2013 and first published on 03 Jan 2013


Article type: Communication
DOI: 10.1039/C2CC38954A
Citation: Chem. Commun., 2013,49, 1651-1653
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    Stereoselective access to heteroarylmethylene-substituted pyrrolidines: fully organocatalytic Mannich–hydroamination reactions

    A. Jean, J. Blanchet, J. Rouden, J. Maddaluno and M. De Paolis, Chem. Commun., 2013, 49, 1651
    DOI: 10.1039/C2CC38954A

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