Room temperature zinc-mediated diastereoselective allylation or propargylation of isatin-derived N-tert-butanesulfinyl ketimines for synthesis of highly enantiomerically enriched tetrasubstituted 3-aminooxindoles is described.
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Zn-mediated asymmetric allylation of N-tert-butanesulfinyl ketimines: an efficient and practical access to chiral quaternary 3-aminooxindoles
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State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, People's Republic of China
E-mail: xumh@mail.shcnc.ac.cn ;
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Tel: +86 21 5080 7388
E-mail: xumh@mail.shcnc.ac.cn ;
Fax: +86 21 5080 7388 ;
Tel: +86 21 5080 7388
Chem. Commun., 2013,49, 1327-1329
DOI: 10.1039/C2CC38600C
Received 30 Nov 2012, Accepted 21 Dec 2012
First published online 21 Dec 2012
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