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Issue 13, 2013
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A two-photon fluorescent probe for amyloid-β plaques in living mice

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Abstract

We report a small molecule two-photon probe (SAD1) that shows a significant TP action cross section (170 GM), binds to Aβ plaques specifically, readily enters the brain through the BBB, and can directly 3D monitor the individual Aβ plaque in living transgenic mice at more than 380 μm depths.

Graphical abstract: A two-photon fluorescent probe for amyloid-β plaques in living mice

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Publication details

The article was received on 29 Nov 2012, accepted on 19 Dec 2012 and first published on 20 Dec 2012


Article type: Communication
DOI: 10.1039/C2CC38570H
Citation: Chem. Commun., 2013,49, 1303-1305
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    A two-photon fluorescent probe for amyloid-β plaques in living mice

    C. H. Heo, K. H. Kim, H. J. Kim, S. H. Baik, H. Song, Y. S. Kim, J. Lee, I. Mook-jung and H. M. Kim, Chem. Commun., 2013, 49, 1303
    DOI: 10.1039/C2CC38570H

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