Issue 13, 2013
From the journal:

Chemical Communications

A two-photonfluorescent probe for amyloid-β plaques in living mice†

Cheol Ho Heo,‡a   Kyung Ho Kim,‡b   Hyung Joong Kim,a   Sung Hoon Baik,b   Hyundong Song,b   Yong Soo Kim,c   Jeewoo Lee,c   Inhee Mook-jung*b  and  Hwan Myung Kim*a  

* Corresponding authors

a Division of Energy Systems Research, Ajou University, Suwon, Korea
E-mail: kimhm@ajou.ac.kr

b Department of Biochemistry and Biological Sciences College of Medicine, Seoul National University, Seoul, Korea
E-mail: inhee@snu.ac.kr

c College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, Korea

Abstract

We report a small molecule two-photon probe (SAD1) that shows a significant TP action cross section (170 GM), binds to Aβ plaques specifically, readily enters the brain through the BBB, and can directly 3D monitor the individual Aβ plaque in living transgenic mice at more than 380 μm depths.

Graphical abstract: A two-photon fluorescent probe for amyloid-β plaques in living mice

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Article information

DOI
https://doi.org/10.1039/C2CC38570H
Article type
Communication
Submitted
29 Nov 2012
Accepted
19 Dec 2012
First published
20 Dec 2012

Chem. Commun., 2013,49, 1303-1305

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A two-photon fluorescent probe for amyloid-β plaques in living mice

C. H. Heo, K. H. Kim, H. J. Kim, S. H. Baik, H. Song, Y. S. Kim, J. Lee, I. Mook-jung and H. M. Kim, Chem. Commun., 2013, 49, 1303 DOI: 10.1039/C2CC38570H

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